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Seed Oil Free Kitchen / The reading room

The Research Shelf

Original papers and thoughtful reading, organized so you can see what kind of evidence sits behind a claim.

A source is more useful when you know what it can—and cannot—tell you.

Read the original paper, look at the people or models studied, and notice what replaced what. A study of repeated frying is not the same as a study of an oil eaten in a mixed diet.

Articles & personal perspectives

These are useful for understanding an author’s position. They are commentary rather than clinical trials, and the strength of each claim depends on the evidence behind it.

Dr. Cate Shanahan · Commentary

The eight oils Dr. Cate focuses on

Her introduction to the oil categories she recommends avoiding and the framework behind that advice.

Read “The Hateful Eight” ↗
Dr. Cate Shanahan · Commentary

Why are seed oils unhealthy?

Dr. Cate’s argument focuses on processing and oxidation. Read it alongside human outcome research to distinguish a proposed mechanism from a demonstrated clinical effect.

Read Dr. Cate’s article ↗
Dr. Cate Shanahan · Reference article

Seed oil FAQs

Definitions and answers from Dr. Cate’s perspective, including how she distinguishes seed oils from the broader category of vegetable oils.

Read the FAQs ↗

Reviews of human trials

Systematic review · 2012

Linoleic acid & inflammatory markers

Johnson and Fritsche reviewed 15 randomized trials in healthy people. They found virtually no evidence that adding linoleic acid increased the measured inflammatory markers. This directly tests a common inflammation claim; it does not answer every question about processed foods or repeatedly heated oil.

Read the review at PubMed ↗
Cochrane review · 2018

Omega-6 fats & cardiovascular outcomes

This review included 19 trials and 6,461 adults. Increasing omega-6 fats may have little or no effect on overall deaths or cardiovascular events, with possible reduction in heart attacks. Many outcome estimates were uncertain because of limitations in the studies.

Read the Cochrane review ↗

Randomized trial reanalyses

Recovered historical trial data · BMJ, 2016

The Minnesota Coronary Experiment

A reanalysis of a 1968–1973 trial found that replacing saturated fat with a linoleic-acid-rich intervention lowered cholesterol but did not demonstrate a mortality benefit in the recovered data. Incomplete data and the historical institutional setting limit how widely the result can be applied.

Read the BMJ paper ↗

Observational human research

Pooled analysis of 30 cohorts · Circulation, 2019

Fatty-acid biomarkers & heart disease

Higher linoleic acid biomarkers were associated with lower risks of several cardiovascular outcomes. These are associations, not proof that changing one oil causes those outcomes. Other diet and lifestyle differences may contribute.

Read the pooled analysis ↗

Animal & mechanistic research

Animal study · Endocrinology, 2020

Soybean oil diets & gene expression in mice

Researchers reported changes in hypothalamic gene expression in male mice fed high-fat soybean-oil diets. Both conventional and lower-linoleic soybean oils produced changes, so the finding does not isolate linoleic acid as the cause. This study generates questions; it does not establish a human disease risk.

Read the original study ↗
My choice, and the evidence.

I choose to cook without these oils. That choice does not require treating every proposed harm as settled science. Human trial evidence does not support a blanket claim that linoleic acid causes inflammation.